منابع مشابه
The Enzymatic Reduction of A’-3-ketosteroids
Many previous studies (1) have indicated that cr,/?-unsaturated 3-ketosteroids are metabolized primarily by reductive reactions involving ring A. First, the double bond and then the carbonyl group are reduced, resulting in so called “tetrahydro” steroids. An earlier report from this laboratory (2) described an extract of rat liver which catalyzed both of these processes. The partial purificatio...
متن کاملOrigin of urinary nonconjugated 19-nor-deoxycorticosterone and metabolism of infused radiolabeled 19-nor-deoxycorticosterone in men and women.
It is known that 19-nor-deoxycorticosterone (19-nor-DOC) is a potent mineralocorticosteroid that is present in urine of rats and humans in a free, i.e., nonconjugated, form. In some forms of hypertension in rats, the levels of free 19-nor-DOC in urine are increased compared with those in urine of normotensive animals. Yet, despite the potential importance of this mineralocorticosteroid in the p...
متن کامل(E)-17β,19-Epoxymethano-17,23,24-tridemethyl-4-nor-5β,18α-olean-3-one oxime
In the penta-cyclic triterpenoide skeleton of the title mol-ecule, C(27)H(43)NO(2) [systematic name: (3E,3aS,5aR,5bR,7aR,11R,11aR,11bR,13aR,13bR)-5a,5b,10,10,13b-penta-methyl-icosa-hydro-1H-11,7a-(epoxy-methano)cyclo-penta-[a]chrysen-3-one oxime], the five-membered ring A has an envelope conformation, while the six-membered rings B-E adopt chair conformations. Rings A and B are cis-fused. The h...
متن کاملTotal synthesis of dl-19-nor-16,17-dehydroprogesterone.
dl-2-(7,11-Dimethyl-3,7,11 - trans,trans-dodecatrienyl)-3-methyl-cyclopent-2-enol was prepared by reduction of the corresponding ketone. This tetraenol, on treatment with trifluoroacetic acid, underwent stereoselective cyclization to give dl-3,17-dimethyl-A-nor-D-homoestra-3,16-diene. This tetracyclic material was readily converted, by oxidative cleavage to the bicyclic triketo aldehyde followe...
متن کامل19-Nor-deoxycorticosterone production from aldosterone-producing adenomas.
19-Nor-deoxycorticosterone (19-nor-DOC), a hypertensinogenic mineralocorticoid, equipotent with aldosterone and independent of the renin-angiotensin system, is synthesized in the kidney and excreted in excess in the urine of patients with aldosterone-producing adenomas. This current study evaluated the adrenal and renal venous levels of aldosterone and 19-nor-DOC after adrenal and renal venous ...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1960
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.8.84